Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap

Narrowing the gap.

Since 1981 AIDS has illuminated, like a roving searchlight, a series of ethical questions, which extend far beyond the apparently narrow limits of one disease. It has revealed, one by one, human attitudes and behaviours that were previously unquestioned, or unobserved based on unidentified but shaky pre-suppositions. This commentary oVers two contrasting perspectives on the problems facing deve...

Narrowing the Nutrition Gap:

Humanized Mouse Models of Staphylococcus aureus Infection

Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulen...

Humanized Mouse Models for Transplant Immunology.

Our understanding of the molecular pathways that control immune responses, particularly immunomodulatory molecules that control the extent and duration of an immune response, have led to new approaches in the field of transplantation immunology to induce allograft survival. These molecular pathways are being defined precisely in murine models and translated into clinical practice; however, many...

Mouse xenograft models vs GEM models for human cancer therapeutics.